Wednesday, May 13, 2020
Use a Function as a Parameter in Another Function
In Delphi, procedural types (method pointers) allow you to treat procedures and functions as values that can be assigned to variables or passed to other procedures and functions. Heres how to call a function (or procedure) as a parameter of another function (or procedure) : Declare the function (or procedure) that will be used as a parameter. In the example below, this is TFunctionParameter.Define a function that will accept another function as a parameter. In the example below this is DynamicFunction type à à TFunctionParameter function(const value : integer) : string;...function One(const value : integer) : string;begin à à result : IntToStr(value) ; end;function Two(const value : integer) : string;begin à à result : IntToStr(2 * value) ; end;function DynamicFunction(f : TFunctionParameter) : string;begin à à result : f(2006) ; end;...//Example usage: var à às : string; begin à às : DynamicFunction(One) ; à à ShowMessage(s) ; //will display 2006 à às : DynamicFunction(Two) ; à à ShowMessage(s) ; // will display 4012end; Important Notes Of course, you decide on the signature of the TFunctionParameter: whether it is a procedure or a function, how many parameters does it take, etc.If TFunctionParameter is a method (of an instance object) you need to add the words of object to the procedural type name, as in:TFunctionParameter function(const value : integer) : string of object;If you expect nil to be specified as the f parameter, you should test for this using the Assigned function.Fixing the Incompatible type: method pointer and regular procedure
Wednesday, May 6, 2020
Animal Histology Free Essays
Where do granular WBCs come from? Granulopoiesis ââ¬â formation of granular leukocytes (WBCs) This process occurs in bone marrow along side erythropoiesis with each type (eosinophil, basophil, neutrophil) going through its own pathway. Two processes take place simultaneously: (1) nuclei condense to adult form (bi-lobed, multi-lobed, etc) and (2) the cell begins to synthesize and collect its specific granule population. I. We will write a custom essay sample on Animal Histology or any similar topic only for you Order Now Start with CFU-S WBC 1. Begin with: promyelocyte (big committed stem cell which commits right away to become either a neutrophilic myelocyte, basophilic myelocyte, or eosinophile myeocyte) a. Myelocytes have a begun nuclear changes, possessing a round nucleus or one that is flatten on one side. The cytoplasm shows a minimum of specific granules (eosinophilic or basophilic or azurophilic) 2. Metamyelocyte (MM) b. Metamyelocytes have begun nuclear indentation (horseshoe shaped to mature morphology) and an increase in specific granules 3. Stab Cells ***EXCLUSIVE ONLY TO NEUTROPHILS*** c. Stab Cells or Band Metamyelocytes are unique to the neutrophil lineage. These cells, approximately the size of mature PMNs have a deep horseshoe or ring-like morphology to their nuclei . Adult Cells final nuclear morphology + specific granules ââ¬â occur in bone marrow next to developing RBC II. Back in Circulation, last type of WBC: Agranular WBC A. Monocyte a. 2-8% WBC b. LANDMARK: largest circulating WBC 15-20 micron dm (3-4X RBC) c. Nucleus: irregular shaped or horseshoe shape BUT UNLIKE STAB CELLS monocytes are seen in circulation while stab cells are found only in bone marrow d. Pr ecursor to LCT macrophages B. Lymphocyte e. 2nd most common WBC (after neutrophils) 30% WBC f. Dm: 8-10 micron (about a RBC) g. Nucleus fills cell, leaving a royal blue rim of cytoplasm h. Fxn: produce antibodies, secretory cell, has lost of rER, lots of ribosomes, therefore basophilic staining Components of the Circulatory System The circulatory system includes both the blood vascular system and the lymph vascular system. The blood vascular system includes the heart, arteries, arterioles, capillaries, venules, and veins. A. Intro to the System a. Pump = heart; in reality 2 pumps sitting side by side: (1) the pulmonary circuit and (2) the systematic circuit i. ight half of the heart pumps blood into the pulmonary circuit via the pulmonary artery to the lungs and back to the heart via the pulmonary vein ii. left half of heart then pumps the oxygenated blood into the systematic circuit via the Aorta. In the systemic capillaries oxygen and nutrients leave the blood and waste materials (i. e. CO2) picked up and returned to the heart b. Arteries iii. Decrease in size to arterioles iv. Strong-walled tubes and are d istribution system; decide who gets how much c. Arterioles terminate in capillaries v. Capillaries are organized in beds vi. Site of exchange between blood and tissue d. Return to heart via venules, then small veins, then veins, and finally the heart vii. Pulmonary vein enters left heart, vena cava comes to right I. Arteries In general, three types of arteries are found in the body: (1) Elastic Arteries, (2) Muscular Arteries, and (3) Arterioles. All three types are composed of three coats or tunics: (1) tunica intima (inner most), (2) tunica media (middle), and (3) adventitia (outer most). A. Muscular Arteries a. Most common type of artery . Distributing system: where to send blood and controls Blood Pressure (use muscular layer to control lumen size) c. Composition: i. tunica intima: composed of an inner endothelial lining sitting on an elastic lamina ii. tunica media: the thickest layer, is composed of spiral smooth muscle cells held together by elastic fibers and an encircling elastic lamina iii. tunica adventitia: composed of fibroelastic connective tissue, with m uch of its elastic component contributing to the make up of the elastic lamina surrounding the media. 1. This layer can be as thick as to 2/3 of that of the media 2. Collagen plus biggest ccn of elastin in muscular arteries, gives recoil ability B. Elastic Artery d. Exit vessels of the heart (pulmonary artery and aorta) e. Gives diastolic number of BP f. Composition: iv. Intima: much thicker (20%) due to increased elastin v. Media: MAJOR DIFFERENCE increased amount of elastic fibers arranged in concentric laminae plus some smooth muscle vi. Adventitia: similar to the muscular artery, except being much thinner, less elastin and more collagen to restrict overexpansion C. Arteriole g. Pressure reducers, donââ¬â¢t want blood to come surging into capillaries h. Composition: contain the same three tunicas, but each is greatly reduced. The intima consist of an endothelium on a basement lamina; the media contains only three layers of smooth muscle cells; and the adventitia thin II. Capillaries in the Body Capillaries are the thinnest walled of all the blood vessels and represent the site of gas and nutrient exchange in the systemic circulatory system. A capillary is composed of endothelial cells, surrounded by a basement membrane A. Continuous Cap (Rare) . Part of any time of blood barrier b. At places you donââ¬â¢t want leaks ex brain c. Sealed with zonula occludens (tight jxns) B. Fenestrated Cap (Most common) d. Riddled with pores to allow exchange e. Produces transudate- maintains osmotic homeostasis (composed of water and ions) f. Exudate: what you make when not normal (water, ions, proteins, cells) Note: Exudate = water + ions + proteins + cell s = infections III. Venus System (Return to the heart System) A. Venules a. Capillaries plus extra layers of pericytes b. Collecting venule wrapped in CT (T. dventia) c. Pericytes turn to smooth muscle (T. media) B. Veins d. T. intimia: no elastin lamina thus NO RIBBON CANDY e. T media: thin layer of muscle f. T adventia: thickest layer g. Veins carry bad oxygen poor blood, the media and adventitia cells are supplied with a separate vascular system. These vessels are called the vaso vasorum and are also found in the walls of large arteries (in T. adventia/T media) h. Veins have valves to prevent blood from backflowing i. Leaflet valves- infolding of the tunica intima ii. Abnormal: varicose veins How to cite Animal Histology, Papers
Monday, May 4, 2020
A Time to Kill free essay sample
I want to tell you a story. Im going to ask you all to close your eyes while I tell you the story. I want you to listen to me. I want you to listen to yourselvesâ⬠¦. Can you see her? Her raped, beaten, broken body soaked in their urine, soaked in their semen, soaked in her blood, left to die. Can you see her? I want you to picture that little girl. ââ¬Å"Now imagine shes white! â⬠(Schumacher, 1996) In the 1996 release of his film A Time to Kill, film director Joel Schumacher submits a formidable adaptation of John Grishams 1989 legal thriller novel of the same name. The filmââ¬â¢s plot, set in the Deep South (Mississippi) involves the rape of a young black girl and the arrest of white rapists responsible and their subsequent murder by the girls father. The remainder of the film then focuses on the trial of the killer, who surprisingly chooses a young unheralded white male lawyer to defend him. At issue are several questions, to be approached and responded to from the Christian tradition. The questions are as follows: 1. Why does Carl Lee take the law into his own hands? 2. Why does Jake take Carl Leeââ¬â¢s case? 3. Jake indicates to Carl Lee that they are friends. Carl Lee corrects him quickly. What is Carl Leeââ¬â¢s rationale? Race, defensibility, access to resources 4. Explain the impact of the 2 psychologistsââ¬â¢ testimony. 5. Explain the impact of the deputy who was shot during Carl Leeââ¬â¢s revenge. 6. Why is Jakeââ¬â¢s closing argument so effective? What type of strategy is he using? 7. Why does Jake bring his family to Carl Leeââ¬â¢s party at the end of the movie? My summation is as follows: (1)Carl Lee decides to take up arms once he is confident that the violators of his daughter would likely walk free or receive light punitive sentences for their vicious assault. Quite frankly, while his lawyer vies to go for he insanity defense, Carl Lee informs all that he, in fact, was not insane during commission of the murders. What is clear is that, due to the racial climate, Carl Lee felt that ââ¬Ëjusticeââ¬â¢ could only be served in this instance â⬠¦ if he meted it out himself as prejudice would surely veil justice as it had many times over. ââ¬Å"Yes, they deserved to die ââ¬â and I hope they burn in hellâ⬠(Schumacher, 1996) is Carl Leeââ¬â¢s response when asked what wouldââ¬â¢ve been a fair sentence to those that nearly fatally assaults his daughter. (2)It is my opinion that Jake takes on the case of Carl Lee due to several factors. My first notion is that he felt as if he and Carl Lee were ââ¬Ëneighborsââ¬â¢, as Carl Leeââ¬â¢s brother had previously been helped by the lawyer; not to mention that both men had daughters that were practically the same age. Moreover, while Jake was fully aware of the practical possibility of the rapists ââ¬Ëgetting off easyââ¬â¢, he realized that racial prejudice within the law was unjust. He seemed to relate to and understand Carl Leeââ¬â¢s plight and providing a good defense was ultimately the ââ¬Ëright thing to doââ¬â¢. (3)While meeting his client in jail, Jake makes the naive mistake of referring to Carl Lee as a friend. Understandably so, Carl Lee takes offense to such a characterization as he reminds the counselor that he had never visited the home of this ââ¬Ëso-calledââ¬â¢ friend and also that their girls (while peers) would never have the opportunity to play together. Carl Lee goes on to dispute Jakeââ¬â¢s naive approach to race relations in the South and informs him (Jake) that he is, in fact, ââ¬Ëthe enemyââ¬â¢. Carl Lee grabs his assessment of their relationship primarily due to his pragmatic world view. He was Black and Jake was white. More importantly to Carl Lee was that the jury, which held his life in their hands, would also be lily-white. Jake was not chosen for representation due to friendship or otherwise; but, simply because he would be in a better position to understand what would be needed to convince white people to view the world (and thus his situation and/or circumstance) differently. Carl Lee would add, ââ¬Å"You are my secret weapon because you are one of the bad guys. You dont mean to be but you are. Its how you was raisedâ⬠. (Schumacher, 1996) (4)On the witness stand, during the trial of Carl Lee, there was expert testimony from separate and distinct psychologistsââ¬â¢. The one, a Dr. Rodeheaver, the more impressionable of the two, was an agent of the State. Dr. Rodeheaverââ¬â¢s testimony, while definitely stirring, seemed to shed light on civil injustices used to finance the Stateââ¬â¢s mental institutions. This testimony, which ordinarily would have been discredited, , was seemingly taken with a ââ¬Ëgrain of saltââ¬â¢ by the all-white jury who did not think outside of the black/white dichotomy. Another psychologist, presented as a ââ¬Ëdefenseââ¬â¢ expert would wound up hurting his own cause as he was exposed as a drunken ââ¬Ëhas-beenââ¬â¢ bearing no confidence and even less self respect. (5)While carrying out what he surely felt was ââ¬Ëjusticeââ¬â¢, Carl Lee (father of the assaulted child) mistakenly shot a town deputy. This deputy, who had to undergo an amputation due to Carl Leeââ¬â¢s recklessness, proclaimed to the jury, the judge and the world, ââ¬Å"I got a little girl. Somebody rapes her, hes a dead dog. Ill blow him away just like Carl Lee didâ⬠. (Schumacher, 1996) Deputy Looney goes on to command the jury to ââ¬Å"turn him looseâ⬠regarding Carl Leeââ¬â¢s future. The impact of Looneyââ¬â¢s testimony, I felt, was a breakthrough in the case as ââ¬Ëfinallyââ¬â¢, it seemed that a white face (and one that was nearly killed by the gunfire) was relating to the injustice prevalent in Deep Southern courthouses. Whether proximity or empathy, Deputy Looneyââ¬â¢s testimony certainly opened eyes in the courtroom and the viewing audience; it actually got the jury to thinkingâ⬠¦. â⬠what would I have done, IF I were Carl Leeâ⬠? (6)During the movie, Jake calls on God ââ¬â in the form of human resource, as he seeks advice from his debunked mentor; a former law professor who tells him, ââ¬Å"Your job is to find justice no matter how well she hides herself. And, struggle as he may, even at one point willing to cop a plea, Jake throws all caution to the wind (even at the cost of losing his everything) to find the truth. In his closing statement to the jury, he states, ââ¬Å"I set out to prove a black man could receive a fair trial in the south, that we are all equal in the eyes of the law. Thats not the truth, because the eyes of the law are human eyes yours and mine and until we can see each other as equals, justice is never going to be evenhanded. It will remain nothing more than a reflection of our own prejudices, so until that day we have a duty under God to seek the truth, not with our eyes and not with our minds where fear and hate turn commonality into prejudice, but with our hearts where we dont know better. (Schumacher, 1996) As denoted in this paperââ¬â¢s opening quote, Jake Brigance uses the jurorââ¬â¢s own hearts to free their souls. Having been primed by Deputy Looney, the jury (and the viewing audience) finally is able to realize their own veiled prejudices; and, it is this ââ¬Ëaffectââ¬â¢ that brings warmness to all witnessing Jakeââ¬â¢s rhetorical deliverance. Whet her we would have done as Carl Lee did, we now could definitely ââ¬Ëfeelââ¬â¢ what he must have felt as an (excluded) individual seeking justice. (7)The last scene of the film brings the point of community to the forefront. By inducing inclusion into the hearts and minds of the all-white jury, Jake is able to obtain a ââ¬Ënot guiltyââ¬â¢ verdict. Just like in a Rocky movie, viewers were cheering the underdog on by filmââ¬â¢s end. Naive in his approachâ⬠¦. inexperienced in matters heââ¬â¢d just overcome, Jake (victorious, acclaimed and relieved) sought to validate his sincerity by visiting Carl Leeââ¬â¢s home. As mentioned, while fully aware of the social climate (as it pertained to race), Jake had and still remained an idealist ââ¬â seeing a world without racial walls. The world had showed him a different reality; yet, still, ever the dreamer, Jake was insistent. If he and Carl Lee werenââ¬â¢t ââ¬Å"friendsââ¬â¢ before, Jake saw no reason why they should not be. Moreover, according to Jake ââ¬â his diluted view of race relations may have been needed to be updated ââ¬â but the idealistic nature of his being (a color equal world) would need to exhibit what he envisioned. Carl Lee had once told him that their daughters would never play together. I smile as I type that â⬠¦ Jake realized that he (as a white) would need to extend the olive branch to address the racial situation from the top-down, as opposed to the bottom-up angle he once believed. And finally, Chapter 5, Building Community (Windley-Daoust, 2008) articulates the importance of ââ¬Ëcommunityââ¬â¢ as a human survival tool. Specifically, it addresses Jesusââ¬â¢ idea of whom and/or what constitutes a ââ¬Ëneighborââ¬â¢ as it is mentioned that we ought to love our neighbor as ourselves. Neighbor, as it meant in the Gospel, simply means ââ¬Ëallââ¬â¢. The subject of exclusion versus inclusion (in the sense of community) is discussed at depth within the chapter â⬠¦ and, it is to that end that I address the question presented within the text. â⬠¢Ã¢â¬Å"Who is excluded from a community to which you belong? Why are they excluded? How does their exclusion hurt them? How does it hurt the whole community? â⬠(Windley-Daoust, 2008, p. 151) I actually had a struggle with answering this question because (initially) I took the inquiry personally. Having virtually no prejudices to mention, I couldnââ¬â¢t figure out how to answer succinctly; but after thought, the question doesnââ¬â¢t address me or my outlook but rather that of my community. That being said ââ¬â the most ââ¬Ëexcludedââ¬â¢ of my community would have to be those that are addicted to crack cocaine. Strangely enough, those that distribute the highly-addictive substance within and throughout my community are lauded and placed on economic pedestals while those that actually use the peddled product are oft-times ostracized and detested as ââ¬Ëless thanââ¬â¢. I would suppose such an attitude is employed due to the personal (proximal) damage done by the users (i. e. , thievery, child mistreatment, uncleaniness) which cause such an position against all; yet, ââ¬Å"the way we treat others is based on the way we view themâ⬠as elucidated in our text. Windley-Daoust, 2008, p. 151) What is lost in stereotyping ââ¬Ëcrack headsââ¬â¢ within the community is the danger of ââ¬Ëpigeon-holingââ¬â¢ an entire segment of the population, thus depriving them and ourselves of the God-given gifts and talents that they possess. Moreover, it is not uncommon to hear people say that ââ¬Å"once a crack head, always a crack headâ⬠; which many times will compel an individual to believe that they have little or value to add to such a huge human existence. With education and understanding (and prayer), hopefully, the community ââ¬Ëat largeââ¬â¢ will come to realize that addiction is a disease and that drug use is merely a symptom of a much larger societal ill. And, as long as ââ¬Ëexclusionââ¬â¢ on any level exists, we (as a collective) will always fall short of reaching our human potential in the eyes of God.
Sunday, March 29, 2020
Turkey free essay sample
Turkey BY ntm289 Abstract This paper explores the different characteristics in the economic and cultural aspects in the country of Turkey in relation to introducing a foreign business into a new country. The economic characteristics that will be assessed will be factors such as GDP per capita and GDP growth rate, Inflation and Unemployment, FDI inflows, FDI potential index, and FDI performance index, along with the countrys competitive index. There will be an explanation of how the factors mentioned above have effected the countrys economic freedom in the last 10 years and how it changed, how orruption changed in the last 10 years, and how governance changed in the last 10 years. Lastly it will explore the countrys culture relevant to running a business in Turkey such as the political, legal, social, religious, and gender based aspects along with an evaluation of the Hofstede framework for Turkey. In 2002, Turkey, along with many other countries, suffered from a global economic downturn but came out relatively un-hurt and continued through out the years to work on a more open and free economy (2013 index of). We will write a custom essay sample on Turkey or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Their largely free-market economy is driven by its industry and service sector with 25% of employment coming rom its traditional agriculture
Saturday, March 7, 2020
The My Lai Massacre of the Vietnam War
The My Lai Massacre of the Vietnam War On March 16, 1968, United States Army troops murdered several hundred Vietnamese civilians at the villages of My Lai and My Khe during the Vietnam War. The victims were mostly elderly men, women and children and all non-combatants. Many were also sexually assaulted, tortured or mutilated in one of the most horrifying atrocities of the entire bloody conflict. The official death toll, according to the US government, was 347, though the Vietnamese government asserts that 504 villagers were massacred. In either case, it took months for U.S. officials to catch wind of the actual events of that day, later filing court-martials against 14 officers present during the massacre yet only convicting the second lieutenant to four months in military prison. What Went Wrong at My Lai? The My Lai Massacre took place early in the Tet Offensive, a major push by the Communist Viet Congà - National Front for the Liberation of South Vietnamà - forces to drive out the South Vietnamese government troops and the U.S. Army. In response, the U.S. Army initiated a program of attacking villages that were suspected of harboring or sympathizing with the Viet Cong. Their mandate was to burn houses, kill off livestock and spoil crops and pollute wells in order to deny food, water and shelter to the V.C. and their sympathizers. The 1st Battalion, 20th Infantry Regiment, 11th Brigade of the 23rd Infantry Division, Charlie Company, had suffered almost 30 attacks via booby-trap or land mine, resulting in numerous injuries and five deaths. When Charlie Company received its orders to clear out possible V.C. sympathizers in My Lai, Colonel Oran Henderson authorized his officers to go in there aggressively, close with the enemy and wipe them out for good. Whether the soldiers were ordered to kill women and children is a subject of dispute; certainly, they were authorized to kill suspects as well as combatants but by this point in the war Charlie Company evidently suspected all Vietnamese of collaborating - even 1-year-old babies. The Massacre at My Lai When the American troops entered My Lai, they did not find any Viet Cong soldiers or weapons. Nonetheless, the platoon led by Second Lieutenant William Calley began to fire at what they claimed was an enemy position. Soon, Charlie Company was shooting indiscriminately at any person or animal that moved. Villagers who tried to surrender were shot or bayoneted. A large group of people were herded to an irrigation ditch and mowed down with automatic weapons fire. Women were gang-raped, babies shot at point-blank range and some of the corpses had C Company carved into them with bayonets. Reportedly, when one soldier refused to kill the innocents, Lt. Calley took his weapon away and used it to massacre a group of 70 to 80 villagers. After the initial slaughter, the 3rd Platoon went out to conduct a mop-up operation, which meant killing any of the victims who were still moving amongst the piles of dead. The villages were then burned to the ground. The Aftermath of My Lai: Initial reports of the so-called battle at My Lai claimed that 128 Viet Cong and 22 civilians were killed - à General Westmorelandà even congratulated Charlie Company for their work and the Stars and Stripes magazine lauded the attack. Several months later, though, soldiers who had been present at My Lai but refused to take part in the massacre began to blow the whistle on the true nature and scale of the atrocity. Privates Tom Glen and Ron Ridenhour sent letters to their commanding officers, the State Department, the Joint Chiefs of Staff, and President Nixon exposing Charlie Companys deeds. In November of 1969, the news media got wind of the My Lai story. Journalist Seymour Hersh conducted extensive interviews with Lt. Calley, and the American public responded with revulsion to the details as they slowly filtered out. In November of 1970, the US Army began court-martial proceedings against 14 officers charged with participating in or covering up the My Lai Massacre. In the end, only Lt. William Calley was convicted and sentenced to life in prison for premeditated murder. Calley would serve only four and a half months in military prison, however. The My Lai Massacre is a chilling reminder of what can happen when soldiers cease to regard their opponents as human. It is one of the worst known atrocities of the war in Vietnam.
Wednesday, February 19, 2020
The Pepsi Challenge Case Study Example | Topics and Well Written Essays - 2000 words
The Pepsi Challenge - Case Study Example The case study deals with Pespi Inc. and the issues it faces with the implementation of enterprise software platform throughout the length and breadth of the organisation. The organisation faces challenges on several fronts. It confronts resistance to change - from the different business divisions, high costs of implementation and labour issues. The organisation's transition to a techno savvy business entity has not been smooth and this report aims to analyse the different incidents which that comes across. Autonomy and fragmentation are the biggest obstacles that the organisation has to resolve. Autonomy is charectised by the reluctance of the different divisions to follow suit in pursuance of a central data warehousing system -because of a variety of reasons. Fragmentation is apparent due to the different software and hardware supports on which the different sections of this huge organisation runs. The purpose of this report is to firstly identify the chief areas of concern that the organisation is facing, and secondly suggest alternatives to the top management so that these problems can be overcome. The case brief outlines the steps that the management has already taken to chalk out a path for the organisation towards becoming an IT backed system - which also includes the problems it has encountered on the way. This report aims to explore newer opportunities that could have gone unnoticed by the management. It is understood that the organisation is huge - Pepsi operates in over 200 countries and the group revenues were to the tune of 43,251 million U.S. dollars in the fiscal year of 2008 (We are Performance with Purpose - Pepsico 2008 Annual Report, 2008). So the challenges that such a company would face while implementing a different outlook towards IT would, invariably be enormous. Background The background of the report is a case brief which deals at length with Pepsi, the issues it faces with the implementation of enterprise software and the efforts that need to be taken by the company in order to overcome the situation. The organisation is faced with several challenges - it operates in a highly competitive market, which is heavily dependent on the prices of the raw material and with issues to tackle major socio - political issues across the globe. It is in this background that the company has embarked on a mission to come up with a leaner supply chain and better data warehousing. "We depend on information technology as an enabler to improve the effectiveness of our operations and to interface with our customers, as well as to maintain financial accuracy and efficiency", states the latest annual report of the company (We are Performance with Purpose - Pepsico 2008 Annual Report, 2008). Approach/ Methodology/ Theoretical Framework The case brief required a thorough analysis. It was found necessary to visit the official
Tuesday, February 4, 2020
Biochemistry Case Study Example | Topics and Well Written Essays - 500 words
Biochemistry - Case Study Example This lactate is normally takes back to liver where it would convert back into pyruvate and glucose through process of gluconeogenesis. This glucose is transferred back again muscle and the cycle is completed. In the process of reconversion of glucose six ATP molecules are consumed and hence there is net loss of 4 ATPââ¬â¢s in one cycle. (à Nelson 2005). If this whole process was to occur in muscle only, than there would be excessive loss of energy and muscle wasting just as it was seen with the patient in clinical presentation. There would be net loss of energy instead of production and lactic acid would ultimately start accumulating in the muscle causing lactic acidosis. Moreover, ATP consumption would be faster than its production, some ADP would also be converted into AMP which is ultimately lost in urine and all these are signs of chronic fatigue syndrome or mitochondrial disease. ( Sarah Myhill 2009). A hypothetical defect in pyruvate dehydrogenase or Isocitrate dehydrogenase or à ±-Ketoglutarate dehydrogenase can prevent increase in ATP generation because these enzymes produce NADH in citric acid cycle which is equivalent to 2.5ATPs. Moreover, Succinate dehydrogenase deficiency can also cause this defect since it produces FAD which is equal to 1.5ATPs. These enzymes can greatly damage the production of ATP through. The concentration of NAD+ is maintained in body and it is reconverted and regenerated through other biochemical procedures that occur inside the cell like citric acid cycle (Nesbitt V 2011). NADH and FADH2 from citric acid cycle get used in electron transport chain and undergo oxidative phosphorylation where they use oxygen and converted ADP into ATP by using a molecule of phosphate as well. This is how citric acid products are converted into ATP. Coenzyme Q10 plays a central role in oxidative phosphorylation of cell. It has a very unique role in electron transport chain and is basically lipid soluble and maintains the proton
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